http://bugs.winehq.org/show_bug.cgi?id=58335
--- Comment #23 from Ken Sharp imwellcushtymelike@gmail.com --- You are all over the place here. First you claim that notepad won't even start, now you're saying that Pegasus Mail starts but doesn't draw correctly.
How are you managing to start Pegasus Mail if your Wine is so very broken?
The Pegasus Mail bug has nothing to do with this bug.
I installed Fedora 42 and tested Wine 10.0 and 10.10, including upgrading a wineprefix from Wine 10.0 to 10.10 and there are no issues.
For reasons beyond logic the Wine that came installed with Fedora is Staging 10.4. The Wines from the official repos are all built with new WoW64 which is experimental. Either way they work fine.
There's something very wrong with your system, and Wine's Bugzilla isn't the place to figure out what.
Before logging a bug report in the future, first ask for help on the forum to see if there actually is a Wine bug. https://forum.winehq.org/