http://bugs.winehq.org/show_bug.cgi?id=56713
--- Comment #6 from Antoine Le Gonidec accounts.winehq@vv221.fr ---
So it seems that launching the game (GOG version, cannot speak for anything else) with `Loader.exe` rather than `Vampire.exe` fixes this issue. It also allows the user to play the Unofficial Patch. I think this solves the issue.
While it is a valid workaround for the GOG build of the game, there is no such loader.exe shipped in the game build formerly sold by DotEmu.
I still need to rummage in my boxes collection, see if I still have a copy of the CD-ROM build, but I suspect it would not come with that loader.exe binary either.