http://bugs.winehq.org/show_bug.cgi?id=29815
--- Comment #8 from rmlipman@gmail.com 2012-04-01 16:38:11 CDT --- (In reply to comment #7)
I can't reproduce this in Guild Wars with automatical capturing enabled (Wine 1.4; X-Server 11.4; GeForce 8600 GT with the NVIDIA driver 295.33). If these components aren't updated on your system you should do this and try again.
My setup is wine 1.5.1, xserver 1.12.0, GTX 570 with nvidia driver 295.33
Are you using a virtual desktop? The mouse look jumping happens for me with a virtual desktop and the auto grab mouse setting checked.
I've always used a virtual desktop, so when I tried testing without a virtual desktop I couldn't get the keyboard to input in windowed or fullscreen.