http://bugs.winehq.org/show_bug.cgi?id=5196
------- Additional Comments From madewokherd@gmail.com 2006-07-05 11:43 ------- This looks like bug 1410.
For now, you might be able to work around it by running the program in Xephyr (which doesn't seem to allow the clients to move the mouse around and would prevent wine from centering it). Otherwise, there's probably a hack you could apply.