http://bugs.winehq.org/show_bug.cgi?id=6721
------- Additional Comments From jonathan@ernstfamily.ch 2006-20-11 02:41 ------- Reporter, please tell us if you have solved your problem (this bug is likely invalid).
You shouldn't need to do that, however, as James wrote, you can kill wine using wineserver -k whithout rebooting.